Concise access to indolizidine and pyrroloazepine skeleta via intramolecular Schmidt reactions of azido 1,3-diketones.

نویسندگان

  • Duanpen Lertpibulpanya
  • Stephen P Marsden
چکیده

Readily prepared 2-alkyl-2-azidopropylcycloalkyl-1,3-diones undergo intramolecular Schmidt rearrangement with a range of hard Lewis acids, leading to indolizidinediones and pyrroloazepinediones. Chiral aluminium-based Lewis acids could also be used to mediate this symmetry-breaking transformation, but no significant asymmetric induction was observed.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 4 18  شماره 

صفحات  -

تاریخ انتشار 2006